[HTML][HTML] The mechanism and regulation of chromosomal V (D) J recombination
CH Bassing, W Swat, FW Alt - Cell, 2002 - cell.com
CH Bassing, W Swat, FW Alt
Cell, 2002•cell.comAbstract V (D) J recombination is of fundamental importance to the generation of diverse
antigen receptor repertoires. We review our current understanding of the V (D) J
recombination reaction and how it is regulated during lymphocyte development. We also
discuss how defects in the mechanism or regulation of V (D) J recombination can lead to
human disease.
antigen receptor repertoires. We review our current understanding of the V (D) J
recombination reaction and how it is regulated during lymphocyte development. We also
discuss how defects in the mechanism or regulation of V (D) J recombination can lead to
human disease.
Abstract
V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.
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